Harnessing liposome technology for precision medicine: design, delivery, and clinical impact

Background: Liposomes are microspheres formed by phospholipids and have received attention as sophisticated drug carriers because they can retain both water-soluble and fat-soluble drugs. Their applications have made them very versatile and have resulted in their great exploration in many aspects of therapy.Objective(s):The present review sets out to provide an exhaustive overview of the nature of liposomes, their preparation tactics, measures of their efficiency, and the trending applications of liposomes in contemporary medicine, with a focus on optimization measures and the future of this technology.Materials and Methods: The mini-review of the literature was done with an emphasis on the various methods of liposome preparation, which included the Bangham method, solvent injection methods, as well as the removal methods of detergents. Efficiency was analyzed based on optimization and evaluation parameters, including vesicle size, shape, zeta potential, and in vitro release profile of the drug to evaluate their contribution to formulation efficiency.Results: Recent innovations have resulted in the creation of new generation liposomal systems, such as active targeting liposomes, stimuli-reactive liposomes, and surface-modified liposomes. These advances bring substantive benefits to drug delivery effectiveness and outcomes in the therapeutic arena and decreased systemic toxicities. Liposomal formulations find increasing use in cancer treatment, in the treatment of infectious diseases, and in gene delivery. A number of novel systems are in the clinical trial stage, indicating their translational potential.Conclusion: Liposomes are a very flexible and evolving drug delivery mechanism. The development of improved surface modification, targeting approaches, and stimuli-responsive systems still augers well with the therapeutic potential. Continuing advances in the development and clinical assessment of new liposomal preparations demonstrate the future of these agent-carrying constructs to transform the field of disease management in the domains of cancer, infectious disease, and gene therapy.

کلیدواژه ها:

Antineoplastic agents ، Drug delivery systems ، Gene Therapy ، Liposomes ، Nanomedicine