Curcumin/Ag conjugated nanoparticles confer neuroprotection against hyoscine-induced acute psychosis: behavioral and biochemical evidence

Obejctive(s): Psychosis is a prevalent psychiatric disorder. Chemicals that modulate the dopaminergic system have been the primary treatment, but these drugs have not always been effective, and some have deleterious side effects. During the last several years, a concerted effort has been made to advance the development of novel pharmaceuticals, utilizing approaches such as nanotechnology, natural compounds, and Eastern medicinal practices. Nanotechnology, including Ag-based nanoparticles, is an exciting option for optimizing drug performance, including reduced side effects and improved pharmacological and clinical profiles. The impact of curcumin‐Ag conjugated nanoparticles (Cur/Ag NPs)  was evaluated in a rodent model of psychosis.Materials and Methods: Cur/Ag NPs were synthesized and characterized by FTIR, FE-SEM, EDX, and UV-vis spectrophotometry. The effect of Cur-Ag NPs was determined for several psychosis-related behaviors (Yawning number, rearing number, and stereotype score) and blood levels of the inflammatory factors CRP, TNF-α, and IL-۱β, and cortisol in an animal model of hyoscine-induced psychosis.Results: Cur/Ag NPs modulated the Yawning number, rearing number, and stereotypic score in hyoscine-induced acute psychosis and attenuated the blood levels of inflammatory parameters, including TNF-α, IL-۱β, C-reactive protein, and cortisol. Cur/Ag NPs demonstrated greater efficacy compared to curcumin, altering these effects at lower concentrations.Conclusion: Cur/Ag NPs and Curcumin were effective in a mouse model of psychosis, exhibiting protective effects against hyoscine-induced acute psychosis, and may be potential candidates for further clinical investigation for treating psychosis-related behavior.

کلیدواژه ها:

Psychosis ، Curcumin/Ag conjugated nanoparticles ، Curcumin