Synthesis of Hollow Fiber Membrane PES-Chitosan-Mg(OH)_۲ as a Candidate for Hemodialysis Membrane

Hemodialysis is a therapy for patients with chronic kidney failure using hollow fiber membranes. The use of hollow fiber membranes has encouraged the search for optimal, effective, and biologically safe formulations. This study aims to create, characterize, review the effectiveness and safety of PES-chitosan-Mg(OH)۲ hollow fiber membranes as candidates for hemodialysis membranes. The combination of these three materials is expected to improve the effectiveness and safety of hemodialysis. This membrane was made using a phase inversion method with varying concentrations of chitosan-Mg(OH)۲, then tested with FTIR, SEM, contact angle testing, flux, and BSA, urea, and creatinine rejection capabilities. FTIR results showed a shift in the –OH and –NH bands, indicating hydrogen interaction between PES and chitosan, as well as Mg²⁺ coordination with the chitosan amine group. Sample F۳ with a ۱% chitosan content showed the most optimal results with a porosity of ۵۰.۵۴%, a contact angle of ۶۸.۳۹°, a flux of ۵۴.۳۹ L/m²h, BSA rejection of ۹۶.۲۶%, and urea and creatinine rejection of ۵۷.۷۴% and ۴۸.۹۶%, respectively. APTT, PT, and hemolysis tests confirmed good biocompatibility (<۲% hemolysis). Overall, the PES–chitosan–Mg(OH)₂ membrane shows potential as an alternative material for effective and biologically safe hemodialysis applications.

کلیدواژه ها:

Hemodialysis ، Hollow Fiber ، PES ، Chitosan ، Mg(OH)۲