mRNA Vaccines in Veterinary Medicine: Progress and Prospects for Key Viral Diseases

Background: Vaccines have made a tremendous contribution to veterinary medicine since the ۱۹th century and have been effective in controlling pathogens in animals. Despite the success of traditional vaccines, there are still situations where the shortcomings of these vaccines are evident. In the efforts to prevent infectious diseases, mRNA vaccines showcase a lot of promise due to their many advantages, including rapid development cycles, low risk of insertional mutagenesis, and potential for cost-effective manufacture. Methods: In this review, we provided an overview of some of the recent advances in the field of mRNA vaccines for key veterinary viral diseases, including Foot-and-Mouth Disease, Rabies, Influenza, Classical Swine Fever, Bovine Viral Diarrhea Disease, and Viral Haemorrhagic Septicaemia. Results: Although only a few mRNA vaccines have been tested in animals so far, their success in human medicine has paved the way. In recent years, mRNA vaccines have emerged as a powerful solution for combating emerging and re-emerging infectious diseases such as Foot-and-mouth disease, Rabies, and Influenza and maintaining food security. Conclusion: As viral pathogens continue to threaten livestock and human life, it is anticipated that mRNA vaccines have the potential to play a major role in shaping the future of global health.

کلیدواژه ها:

Veterinary vaccines ، mRNA vaccine ، Immune response ، Lipid Nanoparticles ، Foot-and-Mouth Disease (FMD)