Comparison of the wound healing abilities of Quercus infectoria galls and Teucrium polium hydroethanolic extract in an excisional wound model of diabetic mice

Background: Diabetic wounds are a major problem in patients with diabetes. Quercus infectoria galls (QIE) and Teucrium polium (TPE), which possess antioxidant and anti-inflammatory properties, have been widely used for various therapeutic purposes. This study aimed to investigate the effects of topical application of an ointment prepared from hydroethanolic extracts of QIE and TPE on excisional wound healing in a streptozotocin-induced diabetic BALB/c mouse model. Methods: After induction of diabetes, circular wounds (۵ mm in diameter) were created on the dorsal surface of the mice, which were then divided into five groups. Diabetes was induced by intraperitoneal injection of streptozotocin (۵۵ mg/kg) for four consecutive days. Animals with blood glucose levels above ۴۰۰ mg/dL were considered diabetic. The mice were treated with soft paraffin (control group) and therapeutic doses of ۵% and ۱۰% ointments prepared from QIE and TPE, respectively. To evaluate the effects of the therapeutic ointments on the wound healing process, the wound area and serum levels of tissue antioxidant capacity and malondialdehyde were measured. Results: Our findings showed that topical application of ۴% TPE and QIE ointments significantly (p < ۰.۰۵) reduced tissue malondialdehyde levels and increased tissue antioxidant capacity. Moreover, wound size was significantly (p < ۰.۰۵) reduced. Among the higher doses, TPE essential oil exhibited a better effect. Conclusion: In summary, it can be concluded that ۴% TPE can accelerate the diabetic wound healing process through its antioxidant properties. Future studies should investigate long-term degradation, immune responses, and the scalability of this treatment for clinical applications.

کلیدواژه ها:

Diabetic wound healing ، Wound size ، Quercus infectoria ، Teucrium polium