Effect of Crataegus pontica C. Koch Leaf (Hawthorn) extract on healing of excisional wounds in rat: An animal model study

Background: The objective of the current study was to investigate effects of Crataegus pontica leaf extract on excisional wound healing. Methods: The Cream was prepared using Crataegus pontica leaf extract in a eucerin base at concentration of ۱۰% (w/w). Fifteen healthy adult male Wistar rats were randomized into three groups of five animals each: ۱) SHAM group with only wound creation. ۲) CREAM group: As a control group with wound creation as well as ۵ g cream (Eucerin) administered locally to the wound bed. ۳) TRTMNT group: As a treatment group with wound creation as well as ۵ g cream (Eucerin) at concentration of ۱۰% (w/w) administered locally to the wound bed. Beginning on the first day, the creams were applied to the skin Lesions once per day until complete healing occurred. An excisional wound model was used for biochemical, histopathological, and planimetric assessments. Results: The wound area was significantly reduced in the TRTMNT group compared to other groups (P < ۰.۰۵). Biochemical and quantitative histopathological analyses revealed a significant difference between TRTMNT and other groups (P < ۰.۰۵). Conclusion: Crataegus pontica C. Koch Leaf (Hawthorn) extract showed the potential to improve wound healing significantly. This appeared to work by angiogenesis stimulation, fibroblast proliferation, inflammation reduction, and granulation tissue formation during the initial stages of the healing process. This accelerated healing led to earlier wound area reduction of the damaged area due to the reorganization of granulation tissue and collagen fibers.

کلیدواژه ها:

Crataegus pontica C. Koch Leaf extract ، skin wounds ، wound area