The Effect of Eight Weeks of Aerobic Training with Curcumin Consumption on AIF-۱ and Cytochrome C in the Heart Tissue of Rats Exposed to Cadmium

Introduction: The occurrence of oxidative stress and cardiac apoptosis following cadmium (Cd) poisoning is one of the causes of heart diseases-induced mortality. Although the favorable effect of exercise and antioxidants on the heart has been reported; however, their simultaneous effect is not yet well understood. Therefore, the present study aimed to investigate the effect of eight weeks of aerobic training (AT) with curcumin (Cu) consumption on apoptosis-inducing factor ۱ (AIF-۱) and cytochrome C (Cyt-C) in the heart tissue of rats exposed to Cd. Methods: In this experimental study, ۴۰ male Wistar rats (۸-۱۰ weeks old, weighing ۱۹۰-۲۲۰ g) were divided into ۵ groups including: healthy control (HC), Cd, Cd+Cu, Cd+AT, and Cd+Cu+AT. During eight weeks, the Cd groups received daily ۵ mg/kg Cd dissolved in drinking water; Cu groups received ۱۶۰ µL/kg orally and AT groups ran five sessions per week and each session for ۳۰-۶۰ minutes at a speed of ۱۵ m/min on a ۱۵-degree slope. Results: The AIF-۱ and Cyt-C levels in the Cd+AT, Cd+Cu and Cd+AT+Cu groups were significantly lower than Cd group (P=۰.۰۰۱); in the Cd+AT and Cd+AT+Cu groups were lower than Cd+Cu group (P=۰.۰۰۱) and in the Cd+AT+Cu group were even lower than Cd+AT group (P=۰.۰۰۱). Conclusion: It seems that both AT and Cu appear to individually inhibit specific apoptotic genes. However, their synergistic effect on suppressing apoptotic markers in cardiac tissue following cadmium exposure is significantly greater than that of either substance alone.

کلیدواژه ها:

Exercise ، Curcumin ، Apoptosis ، Heart ، Cadmium