Unexpected Detection of Psilocybin in a ۱۰۰ mg Tramadol Tablet: A Forensic Case Report

Background: Tramadol is a synthetic opioid analgesic prescribed for moderate pain. Psilocybin (۴-phosphoryloxy-N,N-dimethyltryptamine) is a naturally occurring psychoactive compound found in certain mushrooms, often referred to as "magic mushrooms" and is classified as a Schedule I substance. This case report aimed to present the unexpected detection of psilocybin in a ۱۰۰ mg tramadol tablet. Case Presentation: This case report presents the forensic identification of psilocybin in a tablet labeled as tramadol ۱۰۰ mg. Analysis was conducted using Gas Chromatography–Mass Spectrometry (GC-MS). A high concentration of psilocybin was confirmed, and additionally, ۶۰ mg of tramadol was detected in the analyzed tablet. Discussion: Active compounds of some mushrooms, such as Psilocybe cubensis and Paneolus, have psychotropic agents with hallucinogenic effects. Psilocybin is a prodrug of psilocin, meaning it's converted into psilocin in the body, and Psilocin then acts as a serotonin receptor agonist, particularly on the ۵-HT۲A receptor, leading to visual hallucinations, euphoria, and altered cognition. These effects can be particularly dangerous when combined with other opioids and psychoactive substances that do not have a determined dosage and intensify each other's effects. Conclusion: This case underscores the importance of drug monitoring and advanced toxicological analysis in combating the public health threat posed by drug adulteration.

کلیدواژه ها:

Tramadol ، Psilocybin ، Drug Adulteration ، GC-MS ، Hallucinogens