Comparison of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Two Groups of Patients with Benign and Malignant Salivary Gland Tumors

Introduction: The ratio of neutrophils to peripheral lymphocytes is an inflammatory marker, and, based on previous studies, this ratio is associated with poor survival in several cancers. This study was conducted to compare the neutrophils-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio (PLR) in two groups of patients with benign and malignant salivary gland tumors.Materials and Methods: This study was cross-sectional, comparing two groups of patients with benign and malignant salivary gland masses. During the last ۶ years (from ۲۰۱۸ to ۲۰۲۴), ۳۸۰ Patients with a definite diagnosis of salivary gland tumors were included in the study, and NLR and PLR data were obtained from pre-operation laboratory exams.Results:NLR and PLR were significantly higher on average than in benign masses (P<۰.۰۵). The best cut point was ۲.۲۴ for NLR (sensitivity: ۷۸%, specificity: ۸۰%) and ۱۰۴.۳۵ for PLR (sensitivity: ۶۸%, specificity: ۶۰%).Conclusion: NLR and PLR are easy, practical methods that provide valuable information for diagnosing, assessing severity, and predicting prognosis of various diseases, such as salivary gland masses.

کلیدواژه ها:

neutrophil to lymphocyte ratio ، platelet to lymphocyte ratio ، Benign masses ، Malignant masses ، salivary glands