[۹۹mTc]Tc-MDP uptake in the prostate gland confirmed by SPECT/CT

Prostate cancer remains a leading cause of cancer-related mortality among men worldwide. Technetium-۹۹m methylene diphosphonate ([۹۹mTc]Tc-MDP) bone scintigraphy is commonly employed to detect skeletal metastases due to its high sensitivity in identifying osteoblastic activity. However, [۹۹mTc]Tc-MDP uptake in soft tissues, particularly in the prostate gland, is exceedingly rare. Here, we present a case of a ۷۰-year-old male with acinar prostate adenocarcinoma (Gleason score ۷/۱۰) and persistent lower back pain. [۹۹mTc]Tc-MDP scintigraphy demonstrated abnormal radiotracer uptake in the prostate gland without any evidence of bone metastases. Further evaluation through performing SPECT/CT confirmed the radiotracer uptake in the prostate gland without evidence of calcification. This rare finding emphasizes recognizing atypical imaging patterns and accurately interpreting them, which are important for clinical decision-making. We evaluate the patient regarding the potential mechanisms for such uptake, including dystrophic calcification and localized osteoblastic activity, and discuss the diagnostic implications and future research directions in prostate cancer imaging.

کلیدواژه ها:

prostate cancer ، [۹۹mTc]Tc-MDP ، Bone scintigraphy ، Soft tissue uptake ، Pitfall