Quality Of Life and Functional Outcomes in Patients with Spinal Metastatic Bone Disease: A Retrospective Observational Study

Objectives: Spinal tumors account for ۶-۸% of all bone tumors, with spinal metastatic bone disease being the most commonly found spinal tumor. Patients with spinal metastatic bone disease typically present with symptoms such as pain, neurological impairments, and potential paralysis. The morbidity associated with spinal metastatic bone disease significantly impacts the patients' quality of life. This study aims to investigate the outcomes of quality of life and functional outcomes in patients with spinal metastatic bone disease. Methods: A retrospective observational study was conducted involving patients with spinal metastatic bone disease treated at Dr. Cipto Mangunkusumo Hospital from January ۲۰۲۱ to December ۲۰۲۳. The functional outcomes in this study were assessed using the Short Form-۳۶ (SF-۳۶) and the Oswestry Disability Index (ODI). Results: A total of ۷۳ patients were included in this study, with breast cancer being the most common primary tumor (۵۳%). Significant associations were found between gender and pain component (P = ۰.۰۴۵) and general health component (P = ۰.۰۴۷) of SF-۳۶ scores. Significant differences were also observed in SF-۳۶ components - physical functioning (P = ۰.۰۴۶, r = -۰.۵۶۲), energy/fatigue (P = ۰.۰۳۵, r = -۰.۶۲۱), and general health (P = ۰.۰۲۷, r = -۰.۵۱۳) with age. Significant differences were observed between pre-therapy and post-therapy in SF-۳۶ scores for physical functioning, role limitations due to physical health, energy/fatigue, pain, general health, and ODI. Post-surgery, SF-۳۶ role limitations due to physical health and ODI scores showed significant improvement. No significant relationships were found between pain severity, extremity weakness, type of therapy, and SF-۳۶ or ODI scores. Conclusion: There are significant associations between gender, age, and functional outcomes in patients with spinal metastatic bone disease. There is improvement in SF-۳۶ scores and ODI scores post-therapy, especially after surgery.         Level of evidence: III

کلیدواژه ها:

Oswestry Disability Index ، SF-۳۶ ، Spinal metastatic bone disease