The Effect of Topical Magnesium Sulfate during the Latent Phase of Labor on Cervical Effacement, Dilation, and Labor Duration between Primiparous and Multiparous Women: A Double-Blind Randomized Controlled Trial

Background & Objective: Cervical effacement and dilation are critical components in the progression of labor. Impairments in this process may disrupt the natural course of labor and lead to adverse maternal and neonatal outcomes. This study was conducted with aim to evaluate the effect of topical magnesium sulfate on cervical effacement, dilation, and fetal descent during the latent phase of labor.Materials & Methods: This double-blind randomized controlled trial was conducted on ۱۰۱ term pregnant women (nulliparous and multiparous) divided into intervention and placebo groups. The intervention consisted of applying ۱۰ mL of ۵۰% magnesium sulfate solution (up to two doses) topically to the cervix during vaginal examination in the latent phase of labor. Cervical changes and labor outcomes were assessed at baseline and at ۲- and ۴-hours post-intervention.Results: No significant differences were observed between the groups in baseline maternal age. In nulliparous women, cervical dilation at ۲ and ۴ hours after intervention was significantly higher in the magnesium sulfate group compared to placebo (P=۰.۰۳ and P=۰.۰۱, respectively). Similarly, effacement was significantly greater at both time points (P=۰.۰۰۱ and P=۰.۰۰۷). Although a statistically significant increase in cervical dilation was not observed in multiparous women, labor duration was significantly shorter in both parity groups receiving magnesium sulfate compared to controls (P<۰.۰۱).Conclusion: Topical magnesium sulfate significantly improved cervical effacement, dilation, and reduced labor duration, particularly in nulliparous women. This intervention may serve as a simple and cost-effective strategy to enhance labor management and reduce obstetric interventions, especially in low-resource settings.

کلیدواژه ها:

magnesium sulfate ، Cervical effacement ، Cervical dilation ، labor ، Nulliparous women ، Multiparous women