Cell interactions under controlled of surface substrate

The interactions between cells and substrates are critical for biological processes as intercellular signaling, proliferation and differentiation into tissue or organ formation. The improvement of controlling the cell behavior relevant to another or substrate surface leads the more precise regenerative approaches of tissue engineering. While the presence of extra cellular matrix (ECM) components triggers into cell attachment, a specified chemical group deposited on the substrate surface is able to hamper cell adhesion and can change cell fate to death. Currently, benefiting from nanostructured surfaces has progressed the spatial arrangement of cells with nanometer level resolution. Also, the value of surface roughness as the presence of unique biomolecules or taking the advantage of a specified pattern governs the cell cycle strongly. Herein, we summarized the studies which were focused on the examination of cell fate relative to surface properties. In total, cell activity is directly influenced by surface modifications those try to provide a more biocompatible as well as biologic environment.The interactions between cells and substrates are critical for biological processes as intercellular signaling, proliferation and differentiation into tissue or organ formation. The improvement of controlling the cell behavior relevant to another or substrate surface leads the more precise regenerative approaches of tissue engineering. While the presence of extra cellular matrix (ECM) components triggers into cell attachment, a specified chemical group deposited on the substrate surface is able to hamper cell adhesion and can change cell fate to death. Currently, benefiting from nanostructured surfaces has progressed the spatial arrangement of cells with nanometer level resolution. Also, the value of surface roughness as the presence of unique biomolecules or taking the advantage of a specified pattern governs the cell cycle strongly. Herein, we summarized the studies which were focused on the examination of cell fate relative to surface properties. In total, cell activity is directly influenced by surface modifications those try to provide a more biocompatible as well as biologic environment.

کلیدواژه ها:

cell interaction ، substrate surface ، nanotopography ، fibronectin ، stiffness