Role of Tissue Scaffolds in Skin Wound Healing: A Systematic Review

Researchers have evaluated the biological and synthetic scaffolds to create a similar replacement tissue that is suitable for repairf human skin wounds. In this review we examine the wound healing role of these tissue scaffolds in recent articles. In this study we search multiple medical databases (Pub Med, Science Direct, and ProQuest) with Cochrane guideline and limit the search to “systematic review” for identifying the role of various tissue scaffolds in the wound healing process. We apply these major sources of data without any limitation in terms of study designs. A total of ۳۲۵۴ different articles that are published over the last five years were located through the search, of which ۳۳ met inclusion criteria. Twenty three of these were identified through Science Direct, five from Pub Med and five from Pro Quest. We find various research designs in this study such as case-control, comparative, in vitro scaffold testing and review articles. Research finding that show new scaffolds with various wound healing properties concomitant with application of different growth factors or stem cell seeding. In this article, searching the databases is the most effective means of ensuring that all relevant papers are included in the systematic review. Next step in this research includes further human research about healing effects of proper and biologically tested tissue scaffolds in real patients.Researchers have evaluated the biological and synthetic scaffolds to create a similar replacement tissue that is suitable for repairf human skin wounds. In this review we examine the wound healing role of these tissue scaffolds in recent articles. In this study we search multiple medical databases (Pub Med, Science Direct, and ProQuest) with Cochrane guideline and limit the search to “systematic review” for identifying the role of various tissue scaffolds in the wound healing process. We apply these major sources of data without any limitation in terms of study designs. A total of ۳۲۵۴ different articles that are published over the last five years were located through the search, of which ۳۳ met inclusion criteria. Twenty three of these were identified through Science Direct, five from Pub Med and five from Pro Quest. We find various research designs in this study such as case-control, comparative, in vitro scaffold testing and review articles. Research finding that show new scaffolds with various wound healing properties concomitant with application of different growth factors or stem cell seeding. In this article, searching the databases is the most effective means of ensuring that all relevant papers are included in the systematic review. Next step in this research includes further human research about healing effects of proper and biologically tested tissue scaffolds in real patients.

کلیدواژه ها:

Tissue Scaffolds ، Traumatic Wound Healing ، Skin ، Nursing ، bio-engineering ، Systematic Review