Fabrication of PLGA Conduit for Peripheral Nerve Regeneration

PLGA conduits are widely used experimentally as scaffold for the reconstruction of damaged peripheral nerves. But post traumatic and post operation infections are the most common complications. Silver nanoparticles, as potent antimicrobial agent, have diverse medical applications ranging from silver based wound dressings to silver coated implants. In this study, we fabricated and characterized PLGA/Nanosilver scaffolds for peripheral nerve regeneration and evaluated their antibacterial and cytotoxicity behavior. The results showed that antibacterial efficacy increases with the increase in concentration of silver nanoparticle. This work suggests that nanosilver coating of PLGA scaffolds can increase their infection resistancy and potentially improve peripheral nerve regeneration in a dose dependent menner.PLGA conduits are widely used experimentally as scaffold for the reconstruction of damaged peripheral nerves. But post traumatic and post operation infections are the most common complications. Silver nanoparticles, as potent antimicrobial agent, have diverse medical applications ranging from silver based wound dressings to silver coated implants. In this study, we fabricated and characterized PLGA/Nanosilver scaffolds for peripheral nerve regeneration and evaluated their antibacterial and cytotoxicity behavior. The results showed that antibacterial efficacy increases with the increase in concentration of silver nanoparticle. This work suggests that nanosilver coating of PLGA scaffolds can increase their infection resistancy and potentially improve peripheral nerve regeneration in a dose dependent menner.

کلیدواژه ها:

PLGA ، Nanosilver ، Nerve Growth Conduit ، Peripheral Nerve Regeneration