Evaluation of The Efficacy of Resveratrol and Curcumin on The Expression of Bcl-۲, Bax, and P۵۳ Genes and GAFP Protein in Male Wistar Rats Model Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor seen in humans. Several epidemiological studies have demonstrated the chemo-preventive function of naturally occurring food components in cancer. Polyphenolic compounds of natural origin possess promising therapeutic potential as drugs for the management of glioblastoma and are being explored as potential anticancer agents. Despite the promising benefits of natural polyphenolic compounds, their effectiveness in treating GBM is restricted by their limited bioavailability and permeability through the blood-brain barrier. Several compounds derived from plants have demonstrated potential as antitumor therapeutic agents by augmenting apoptosis-related pathways and causing cell cycle impairment in tumor cells, including those found in GBM cell lines. According to reports, curcumin exhibits noteworthy antitumor properties. The anti-glioblastoma effects of heterogeneous compounds can be attributed to their ability to upregulate apoptosis and autophagy, promote cell cycle arrest, interfere with tumor metabolism, and inhibit proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis. The development of glioblastoma cancer cells was modestly inhibited by the combination of resveratrol and curcumin. We found that the combined treatments resveratrol with curcumin inhibit the Bcl-۲ expression, the reduction of the expression of Bax and P۵۳.The findings of this study offer substantiation that the administration of resveratrol with curcumin in combination may present a compelling alternative for combating GBM. Nevertheless, further clinical trials are necessary to validate the characteristics of these compounds both in vitro and in vivo.Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor seen in humans. Several epidemiological studies have demonstrated the chemo-preventive function of naturally occurring food components in cancer. Polyphenolic compounds of natural origin possess promising therapeutic potential as drugs for the management of glioblastoma and are being explored as potential anticancer agents. Despite the promising benefits of natural polyphenolic compounds, their effectiveness in treating GBM is restricted by their limited bioavailability and permeability through the blood-brain barrier. Several compounds derived from plants have demonstrated potential as antitumor therapeutic agents by augmenting apoptosis-related pathways and causing cell cycle impairment in tumor cells, including those found in GBM cell lines. According to reports, curcumin exhibits noteworthy antitumor properties. The anti-glioblastoma effects of heterogeneous compounds can be attributed to their ability to upregulate apoptosis and autophagy, promote cell cycle arrest, interfere with tumor metabolism, and inhibit proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis. The development of glioblastoma cancer cells was modestly inhibited by the combination of resveratrol and curcumin. We found that the combined treatments resveratrol with curcumin inhibit the Bcl-۲ expression, the reduction of the expression of Bax and P۵۳.The findings of this study offer substantiation that the administration of resveratrol with curcumin in combination may present a compelling alternative for combating GBM. Nevertheless, further clinical trials are necessary to validate the characteristics of these compounds both in vitro and in vivo.