Current Insights into Pathophysiology, Clinical Presentation, and Minimally Invasive Management of Renal Peripelvic Cysts, A Narrative Review

Background: Renal peripelvic (parapelvic) cysts cause hydronephrosis, pain, and obstruction when exceeding ۴-۵ cm due to hilar compression, with elevated IL-۶, TNF-α, and creatinine reflecting inflammation and impaired function.​Objective: This narrative review synthesizes evidence on pathophysiology, diagnosis, and minimally invasive management, emphasizing retroperitoneoscopic decortication versus ureteroscopic drainage outcomes.​Methods: Literature from ۲۰۱۱-۲۰۲۵ (PubMed, Scopus, Web of Science) was reviewed, prioritizing comparative studies, case series (n≥۲۰), and biomarker data; a key ۱۰۰-patient cohort provided head-to-head analysis.​Results: Retroperitoneoscopic decortication shows superior outcomes versus ureteroscopy: shorter operative time (۷۸±۱۸ vs ۱۱۲±۲۴ min), less blood loss (۲۵±۱۵ vs ۵۵±۳۰ mL), faster recovery (hospital stay ۲.۸±۰.۹ vs ۵.۱±۱.۴ days), lower complications (۸% vs ۱۸%), and greater IL-۶/TNF-α decline; recurrence rates similar (۸-۱۰%).​Conclusion: Retroperitoneoscopic decortication is optimal for symptomatic peripelvic cysts, balancing efficacy, safety, and biomarker recovery over ureteroscopy

کلیدواژه ها:

Peripelvic cyst ، Parapelvic cyst ، Retroperitoneoscopic decortication ، Ureteroscopic drainage ، IL-۶ ، TNF-&alpha ، ، Renal cyst management