Consumption Patterns of Antibiotic Prophylaxis Regimens Among Patients Presenting To the Surgical Wards at Bu-Ali Sina Medical and Educational Services Center in Sari, Iran: A Retrospective Cross-Sectional Study

Background: In the context of modern healthcare, surgical interventions are essential yet pose inherent risks, including postoperative infections. Antibiotic prophylaxis plays a pivotal role in mitigating these risks, aiming to prevent surgical site infections (SSIs) and associated complications. This study focuses on the consumption patterns of antibiotic prophylaxis regimens among patients admitted to the surgical wards at Bu Ali Sina Medical and Educational Services Center in Sari, Iran.Methods: This retrospective cross-sectional study involved ۹۷۰ participants undergoing clean or clean-contaminated surgical procedures. The research employed a researcher-made questionnaire covering demographic information, antibiotic details, side effects, duration of administration post-operation, adherence to guidelines, and compliance with ASHP ۲۰۱۳ antibiotic prophylaxis guidelines. Statistical analyses included central tendency and dispersion indicators, Chi-squared test, Fisher's exact test, one-sample Kolmogorov-Smirnov, Mann-Whitney U test, and T-test.Results: The predominant antibiotic categories were cephalosporins, with ceftriaxone and cefazolin accounting for ۶۵.۲% and ۶۱.۸% of prescriptions, respectively. Comparison between orthopedic and ENT surgery groups did not reveal significant differences in antibiotic regimens (P=۰.۰۸۵). However, a noteworthy difference emerged in the duration of antibiotic prophylaxis, with a significant distinction between orthopedic and ENT surgery groups (P=۰.۶۵۰). Compliance with ASHP ۲۰۱۳ guidelines was observed in ۸۴% of cases regarding the timing and type of prescribed antibiotic prophylaxis regimen.Conclusion: This study provides crucial insights into the consumption patterns of antibiotic prophylaxis among surgical patients, emphasizing the prevalence of cephalosporins and revealing distinctions in duration between orthopedic and ENT surgery groups. The findings contribute to optimizing patient outcomes and addressing antimicrobial resistance challenges. As the healthcare community navigates the delicate balance between prophylactic benefits and resistance concerns, these results offer valuable information for policy-making and clinical practices.

کلیدواژه ها:

Consumption patterns ، Antibiotic ، Prophylaxis ، Cephalosporins ، Ceftriaxone ، Cefazolin