The Influence of Low Molecular Weight Heparin and Early Enteral Nutrition on Immune, Coagulation, Inflammatory, and Nutritional Indicators in Hyperlipidemic Acute Pancreatitis: An In-Depth Analysis

Backgrounds: Hyperlipidemic acute pancreatitis (HLAP) is a growing and serious subtype of acute pancreatitis, involving a complicated interaction of metabolic imbalance, widespread inflammation, and clotting irregularities. The potential of low molecular weight heparin (LMWH) and early enteral nutrition (EEN) as supplementary treatments has attracted considerable attention for their ability to influence central disease mechanisms. Methods: This detailed review integrates findings from clinical research, randomized controlled trials, and meta-analyses released between ۲۰۱۰ and ۲۰۲۴, gathered via systematic searches of PubMed, Embase, and Cochrane Library databases. Emphasis was placed on studies assessing how LMWH and EEN affect immune markers (IgA, IgG, IgM), clotting factors (PT, TT, APTT, FIB), inflammatory mediators (TNF-α, IL-۶, IL-۸, CRP), and nutritional indicators (TP, ALB, TRF) in HLAP patients. Results: Current data suggest that using LMWH together with EEN produces better patient results than traditional care alone. Notable outcomes involve a marked decrease in inflammatory markers, better clotting function, higher antibody levels, and improved nutritional measures. This combined method is linked to reduced hospitalization time, quicker return of digestive function, and fewer complications like multiple organ failure. Conclusion: The complementary actions of LMWH and EEN tackle the diverse causes of HLAP. LMWH enhances blood flow in the pancreas while lowering excessive clotting and inflammation, whereas EEN protects intestinal lining and helps regulate immunity. Subsequent studies should aim to establish consistent treatment guidelines and determine which patients would gain the most from this dual therapy.

کلیدواژه ها:

Hyperlipidemic Acute Pancreatitis ، Low Molecular Weight Heparin ، Early Enteral Nutrition ، Immunoglobulin ، Coagulation ، Inflammation ، Nutrition ، Biomarkers