A Comprehensive Review of Statins' Dual Role in Alzheimer's Disease

Aims: Alzheimer's disease (AD), the primary cause of dementia, affects millions. Statins, used for cholesterol lowering, may have a dual role in AD development and treatment, potentially offering neuroprotection but with unclear clinical outcomes and heterogeneous data. This review assesses statins' role, cognitive effects, therapeutic uses, and limitations in AD.Materials and Methods: A systematic search of PubMed, Scopus, and Google Scholar (۱۹۹۵–۲۰۲۴) using MeSH keywords) Alzheimer's Disease, Cognition disorders, Dementia, Memory impairment, Neurodegenerative diseases, Statins( identified ۲۶۸ articles, refined to ۹۸ based on relevance and quality. Studies included primary and secondary research on statins’ cognitive effects.Results: Evidence on statins’ cognitive impact in AD is mixed. Some studies suggest benefits through reduced beta-amyloid (Aβ) production and anti-inflammatory effects, particularly in ApoE۴ carriers or early-stage AD, while others report reversible cognitive impairment, especially with lipophilic statins. Observational studies show conflicting results compared to randomized controlled trials (RCTs), with limitations in study design and dosage variability. Statins therapy is recommended for AD patients with metabolic disorders.Conclusion: Statins’ cholesterol-lowering, anti-inflammatory, and antioxidant properties offer potential neuroprotection, but their impact on AD pathology remains unclear due to heterogeneous data and unexamined dose-response relationships. Long-term RCTs with stratified patient groups (e.g., by statin type, disease stage, or ethnicity) are needed to clarify efficacy and risks.

کلیدواژه ها:

Alzheimer's disease ، Cognitive disorders ، dementia ، Memory impairment ، Neurodegenerative Diseases ، Statins