Confirming the Normal Range for Mebrofenin Liver Function Indices

Objective: To establish normal ranges for [۹۹mTc]TcMebrofenin hepatobiliary scintigraphy (HBS) indices of liver function and the associated uncertainty in clinical measures due to region placement.Methods: ۴۷ patients referred for gallbladder assessment with no history of liver disease were included in the study. Patients underwent dynamic HBS following injection of ۲۰۰ MBq of [۹۹mTc]TcMebrofenin at ۱۰ seconds/frame for ۳۶ frames. Analysis was performed by ۵ experienced technologists using in-house software (MIM Software, Cleveland, Ohio) to establish blood pool (BP) clearance rate (%/min), blood clearance half-time (min), mebrofenin liver uptake rate (MUR) (%/min) and MUR normalised to body-surface-area (MURBSA) (%/min/m۲). Limits of normal ranges (۹۵%) were established and correlation of functional indices with age was investigated. Analysis was repeated after a minimum of ۴ weeks to establish intra-user variability and uncertainty associated with measures. Results: Data were collected for ۲۷ women and ۲۰ men, with an age range of ۲۰ – ۸۱ years. Twenty-seven patients were aged over ۵۰ and ۲۰ patients were aged below ۵۰. The data were found to have a normal distribution. The mean values derived for the entire cohort for BP clearance rate, blood clearance half time, MUR, and MURBSA were ۱۶.۸ ± ۲.۶ %/min, ۴.۳ ± ۰.۷ min, ۱۴.۴ ± ۲.۰ %/min and ۸.۰ ± ۱.۵ %/min/m۲, respectively. No significant difference in values was found between age groups and no correlation between liver function and age was found. The lower range of normal for MURBSA was established as ۵.۱ %/min/m۲, with clinical measures expected to have an uncertainty of ± ۰. ۶ %/min/m۲. Conclusion: The MURBSA value for a patient with normal liver function can be expected to be approximately ۸.۰ ± ۱.۵ %/min/m۲, with a lower limit of normal function at ۵.۱ %/min/m۲. Patients receiving liver surgery or treatment that express MURBSA values below this may be at higher risk and should potentially be treated with caution.

کلیدواژه ها:

Mebrofenin ، Liver ، hepatobiliary scintigraphy ، portal vein embolisation ، radioembolisation