CAKUT Conundrums: Tailoring Kidney Transplants for Congenital Anomalies in Kids

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) represent a spectrum of structural malformations present at birth, affecting approximately ۴.۲ to ۱۰۰۰ per ۱۰,۰۰۰ births worldwide. These include conditions such as posterior urethral valves (PUV), vesicoureteral reflux (VUR), renal hypoplasia, and neurogenic bladder (NGB), which collectively account for nearly half of end-stage renal disease (ESRD) cases in children. CAKUT disrupts normal renal development and urinary flow, leading to progressive chronic kidney disease (CKD) and often necessitating kidney transplantation (KTx) as the optimal renal replacement therapy. While pediatric KTx offers superior outcomes compared to dialysis, including improved growth and quality of life, children with CAKUT face unique conundrums due to underlying anatomical and functional abnormalities. These challenges complicate surgical procedures, elevate post-transplant risks, and demand tailored multidisciplinary strategies. Tailoring kidney transplants for CAKUT in children navigates a labyrinth of anatomical, functional, and infectious pitfalls through rigorous evaluation, adaptive surgery, and vigilant post-op care. This multidisciplinary approach not only salvages grafts but also elevates quality of life, though prospective studies are imperative to refine protocols and resolve lingering conundrums. As pediatric nephrology evolves, addressing these congenital anomalies promises brighter futures for affected kids.

کلیدواژه ها:

CAKUT ، Congenital anomalies ، Kidney Transplants ، Kids