Synthesis, identification, and molecular docking of some new derivatives of ciprofloxacin drug with studying lt's biological activity and anticancer evaluation

The antibacterial action of novel diazine compounds against COX-۲ was predicted, and their anticancer potential was anticipated. FTIR spectroscopy, ۱HNMR, ۱۳CNMR, physical properties, and other techniques were employed to identify and describe the chemicals that were generated. Ciprofloxacin methyl ester molecule [۱] was created by reacting ciprofloxacin with methanol while using intense H۲SO۴. By reacting ciprofloxacin methyl ester with hydrazine hydrate, compound [۲] was produced. With glacial acetic acid acting as a catalyst and a solvent, hydrazide derivative [۲] reacted with maleic anhydride, succinic anhydride, phthalic anhydride, and ۳-nitrophthalic anhydride, respectively, to create diazine compounds [۳-۶]. The compounds were tested against antibacteria, specifically Staphylococcus aureus (G+) and E.Coli, and their cytotoxic efficacy against two human cancer cell lines (A۵۴۹ and MCF-۷) was assessed. The synthesized compounds were subjected to molecular docking tests.

کلیدواژه ها:

Anticancer ، biological activities ، Ciprofloxacin ، Molecular docking