Anticancer applications of poly(butyl cyanoacrylate): Strategies and mechanisms in breast, prostate, lung, and bronchus cancers

In recent years, numerous micro- and nanoformulations of anticancer drugs and agents have been developed to mitigate the side effects and off-target effects related to conventional chemotherapy. Polybutylcyanoacrylate (PBCA) is a biodegradable polymer derived from the cyanoacrylate family. Due to its unique physicochemical features, including biodegradability, biocompatibility, and ease of formulation into nanoparticles, PBCA has obtained significant attention as a drug delivery system, specifically in oncology. PBCA-based nanoparticles can effectively encapsulate and transport chemotherapeutic agents, improving drug targeting, minimizing systemic toxicity, and overcoming multidrug resistance. In this review, novel applications of PBCA in designing drug delivery systems for breast, prostate, and lung cancers have been discussed. The conclusion section also presents clinical limitations to open avenues for future studies.

کلیدواژه ها:

Side Effects ، Conventional chemotherapy ، Polymeric nanoparticles ، Encapsulation ، Anticancer mechanisms