Cellax nanopartciles: Taxane nanoformulations for solid tumor targeting

Nanoparticles (NPs), specifically polymer-modified NPs, have illustrated unique therapeutic advantages compared to bulk materials. Cellax NPs have provided a promising approach to cancer therapy by improving drug delivery, targeting the tumor microenvironment, and potentially overcoming drug resistance, all while reducing overall toxicity compared to traditional taxane treatment. By the flash nanoprecipitation (FNP) method, docetaxel and cabazitaxel have been formulated with polyethylene glycol (PEG) modified-acetylated carboxymethylcellulose (CMC) polymer to increase biocompatibility, bioavailability, specific targeting, and modulate the tumor microenvironment. However, there are some challenges and clinical limitations related to this formulation, encompassing optimum targeted delivery to tumors, overcoming biological barriers, such as the blood-brain barrier (BBB), and maintaining stability in vivo, which should be addressed in future studies. Treatment outcomes of some solid tumors, involving prostate, breast, pancreatic, melanoma, lung cancers, and hepatocellular carcinoma by Cellax NPs have been discussed in this mini-review article based on recent investigations.

کلیدواژه ها:

Docetaxel ، Cabazitaxel ، Acetylated carboxymethylcellulose ، Flash nanoprecipitation ، Tumor Microenvironment ، Blood-Brain Barrier