The Relationship Between Serum ۲۵-Hydroxyvitamin D Level and Stage and Grade of Breast Cancer in Female Patients Referred to Amir Al-Momenin Hospital, Zabol

Background & Objective: Breast cancer is one of the most common cancers in women worldwide. Therefore, the present study was conducted with aim to examine the relationship between the serum level of ۲۵-Hydroxyvitamin D and the stage and grade of breast cancer in female patients referred to Amir Al-Momenin Hospital in Zabol in ۲۰۲۳.Materials & Methods: This descriptive and analytic study was conducted in ۲۰۲۳ on ۲۷ cases of breast cancer with ۲۷ matched controls. Information on breast cancer risk factors, vitamin D and calcium supplementation, and previous history of the disease was obtained by completing a general questionnaire. The blood samples were taken from the studied women and the concentration of ۲۵-Hydroxyvitamin D in the serum was measured by quantitative luminescence method. Then, data were recorded and entered SPSS software for statistical analysis and evaluated using chi-square test. P<۰.۰۵ was considered significant.Results: In this study, ۶ people (۲۲.۲%) had mixed invasive ductal, ۱۹(۷۰.۴%) had invasive ductal carcinoma, and ۲(۷.۴%) had mucinous carcinoma. In terms of the degree of breast cancer, ۳ people (۱۱.۱%) were of mild type, ۱۸(۶۶.۷%) moderate type and ۶ (۲۲.۲%) severe type of breast cancer.Conclusion: No significant difference was observed between the serum level of ۲۵-Hydroxyvitamin D and different degrees of breast cancer. Deficiency of vitamin D in women is a health problem that should be addressed by public health professionals.

کلیدواژه ها:

Breast cancer ، Vitamin D ، ۲۵-hydroxyvitamin D ، Epigenetics