Review on Enhancing Osteogenic Tissue Engineering on the Polymeric Nanofiber Scaffolds Through Advanced Techniques for Bioengineering Applications

Recent advancements in osteogenic tissue engineering are significantly enhancing approaches to bone repair and regeneration, with ۳D bioprinting enabling the precise creation of complex bone structures using bio-inks infused with stem cells and growth factors, smart biomaterials such as nanocomposites and hydrogels engineered to release healing molecules in response to specific conditions to facilitate bone growth, enhanced techniques for isolating and differentiating stem cells into bone-forming cells improving their integration into existing bone while gene therapy allows for targeted delivery of bone-stimulating genes, a focus on developing blood vessel networks within scaffolds to ensure new bone tissue receives essential nutrients, insights into mechanical force influences leading to scaffold designs replicating natural bone stress and strain, and the combination of various materials in hybrid scaffolds aiming to emulate the strength and flexibility of natural bone, alongside improved animal models offering valuable efficacy insights - this study significantly contributes to the field by introducing innovative polymeric nanofiber scaffolds combining hyaluronic acid, gelatin, and varying polyvinyl alcohol concentrations, with its originality in exploring multilayer scaffolds with controlled degradation rates showed through high technical quality experimental methods and comprehensive characterization, while future research should optimize polymer ratios to enhance mechanical properties and biocompatibility, investigate large-scale production methods, and develop multifunctional scaffolds for comprehensive bone healing.

کلیدواژه ها:

Osteogenic tissue engineering ، Polymeric Nanofiber Scaffolds ، Hyaluronic acid ، Gelatin ، Controlled degradation