An efficient one-pot three-component synthesis of a-amino nitriles via Strecker reaction catalyzed by lanthanium(III) chloride

A convenient and efficient one-pot method for the synthesis of a variety of a-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (TMSCN) in the presence of a catalytic amount of LaC۱۳ at room temperature in acetonitrile (MeCN) is described. The significant features of this method are simple work-up procedure, inexpensive and non-toxic catalyst, shorter reaction times and excellent product yields. The catalyst LaC۱۳ can be reused. The reusability of the catalyst has been studied for the synthesis of various amino nitriles.

کلیدواژه ها:

a-amino nitriles ، LaCl۳ ، trimethylsilyl cyanide ، Strecker reaction