Effect of Saliva officinalis Ethanolic Leaf Extracts on Level of Telomerase Enzyme, Biochemical Factors and Oxidative Stress in Major Organs of Aged Rats

Background: Aging as a biological process reduces life quality and is related to a time-dependent decline in cellular function. Aging is known as a primary risk factor for many disorders. Nowadays, aging-related disorders have become a global healthcare challenge. Thus, the present study investigated the impact of saliva officinalis (SF) in aged tissues. Methods: In the current research, ۳۰ aged male rats (twenty month-old) were divided into ۳ groups: aging, aging-low SF (۱۰۰ mg/kg), and aging-high SF (۲۰۰mg/kg). saliva officinalis was gavage for ۲ weeks. Finally, all the aged animals were sacrificed; then, the heart, liver, hippocampus, and right kidney tissues were taken for oxidative stress assessment. The blood sample was collected for the level of urea, creatinine, liver enzymes, oxidant and antioxidant, and telomerase enzyme activity measurement. Results: The results showed that saliva officinalis administration in high a dose decreased oxidative stress in aged tissues significantly. The urea and creatinine levels in the aging-high SF group had a significant reduction in comparison with the aging group. There is an insignificant change in aspartate aminotransferase (AST), while the alanine aminotransferase (ALT) significantly decreased in the aging-high SF group. Using saliva officinalis in low and high doses increased the telomerase enzyme activity notably. Conclusion: This study suggests that the administration of saliva officinalis especially in a high dose (۲۰۰ mg/kg) can be useful in reducing aging-related impairment.

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Keywords: Aging ، Saliva officinalis ، Oxidative stress