Interference of cold agglutinin with RBC parameters in a non-hemolytic case

Background: Cold agglutinin disease is a rare condition affecting ۱ per million population annually. It is usually associated with hemolytic anemia. We report a case of interference of cold agglutinin with red blood cell (RBC) parameters in a non-hemolytic case. Case: A ۳۱-year-old male presented with complaints of a cough and fever. Routine blood investigation revealed normal hemoglobin with low RBC, packed cell volume (PCV), high mean corpuscular volume (MCH), and mean corpuscular hemoglobin concentration (MCHC). The indirect Coombs test was negative. So, interference due to cold agglutinin was suspected, which was confirmed following the disappearance of agglutinin after incubation at ۳۷° C for ۳۰ minutes. Conclusion: The possibility of RBC cold agglutinin should be suspected if there is any mismatch between RBC parameters and appropriate measures should be taken for proper delivery of results.

کلیدواژه ها:

complete blood count ، cold agglutinin ، histograms ، RBC Indices