Mechanisms of resistance to targeted therapies in non-small cell lung cancer (Pharmacology and Therapeutics)

Introduction: Targeted therapy for lung cancer is a treatment that kills cancer cells, can also affect normal cells, and can cause unwanted side effects. Material and Method: In the current study, the issue investigated by reviewing ۳۵ articles (۲۰۱۸-۲۰۲۵) and considering key words such as "lung cancer", " targeted therapy", "cancer", " cell culture", “PDS model” in Scopus, Google scholar and PubMed databases.Findings: The results of the study showed that healthy lung tissue from the same patients used as spheroids. These natural spheroids help measure the toxicity of drugs on healthy lung cells, thus avoiding harmful side effects. Chemotherapy works by killing rapidly dividing cells, such as cancer cells. This treatment works by stopping cells from growing and dividing. These treatments specifically target proteins inside cancer cells that tell cancer cells to multiply. Targeted therapies only kill cancer cells. That's why they're called targeted. Statistics show that ۳۰% to ۴۰% of people receiving targeted therapy develop resistance to the treatment. The spheroid cultures described in this study help identify the most effective treatment for each patient and assess the risk of cancer cell adaptation and resistance to treatments. Conclusion: Lung spheroid models offer hope in the search for personalized cancer treatments and serve as a gateway for the development of anticancer therapies tailored to each individual. The findings also showed that this lung PDS model is an effective in vitro drug-screening tool to identify an optimized treatment for the patient.

کلیدواژه ها:

Lung cancer ، targeted therapy ، cancer cell ، cell culture ، PDS model