Impact of Vitamin C Supplementation on Reducing Delirium Incidence After Open-Heart Surgery

Introduction: Delirium can be a real challenge for patients in intensive care units (ICUs), popping up in about ۳۰% of those who’ve had cardiac surgery. We wanted to see if a little vitamin C could help prevent this confusion after open-heart procedures. Material and methods: We ran a randomized controlled trial with ۱۶۰ adults set for elective heart surgery using cardiopulmonary bypass (CPB) at Shahid Madani Hospital in Tabriz back in ۲۰۱۹. We split them into two groups: ۸۰ got vitamin C (۱۰ cc or ۲ grams intravenously right after CPB started, then ۱ gram daily for two days), and ۸۰ got a placebo (just distilled water). We kept an eye on delirium using the CAM-ICU tool and tracked things like patient details, surgery stats, and any complications. Results: At first, we thought delirium hit ۲۲.۸% of patients (۳۷ people), with the vitamin C group at ۱۵.۲% and the placebo group at ۳۰.۱%—a pretty clear difference (P=۰.۰۲۴). But after a closer look, we spotted a hiccup in how we assigned people, so we adjusted the numbers to ۲۰% total (۳۲ patients), with ۱۲.۵% in the vitamin C group and ۲۷.۵% in the placebo group (P=۰.۰۱۸). Patients with delirium also had longer surgeries, more time on CPB, more bleeding, and extended ICU stays (P<۰.۰۵). Conclusion: It looks like vitamin C might be a helpful tool to keep delirium at bay after heart surgery—pretty exciting stuff!

کلیدواژه ها:

Cardiac Surgery ، delirium ، vitamin C supplementation ، Postoperative complications ، randomized controlled trial