Smoking-induced changes in leptin serum levels and c/EBPalpha-related methylation status of the leptin core promotor during smoking cessation

The damaging effects of smoking: Smokers look ۸ to ۲۰ years older than their actual age. Smoking for ۱۰ minutes reduces oxygen delivery to the skin for an hour. Researchers conducted this study to investigate the relationship between smoking and DNA methylation. DNA methylation is a specific type of epigenetic change that alters a number of biological processes. ۲,۷۲۸ people from different racial and ethnic groups participated in the study. The researchers were able to identify ۴۰۸ methylation markers associated with smoking. Two of these markers were not the same in all participants, and race or ethnicity played a significant role in this difference. The researchers calculated the total nicotine equivalents to determine a measure of smoking. The researchers used data from a database to conduct the first study. Then, biological samples were collected from ۱,۹۹۴ participants to determine each person's smoking dose and the level of DNA methylation across the genome. After examining, the researchers concluded that smoking was associated with DNA methylation at ۴۰۸ sites. ۴۵ new sites were identified. Of these ۴۰۸ sites, two sites played a significant role in changing the risk of developing the disease based on race or ethnicity. In the African American participants who smoked, one site in the CYTH۱ gene was changed. In the Latino participants who smoked, another site in the MYO۱G gene was identified.

کلیدواژه ها:

cancer ، Disease ، risk ، Biological Criteria ، Biological Processes