The Impact of Gut Microbiota on Drug Metabolism and Pharmacokinetics

Intestinal obstruction is not a common disease in human societies. Despite the lack of accurate statistics on the prevalence of intestinal obstruction in Iran and the serious complications of intestinal obstruction in terms of intestinal gangrene and the need for resection of part of the intestine and performing a colostomy (ostomy), and the development of short bowel syndrome, etc., it is important to know the causes of obstruction and the justification of symptoms, as well as to examine its various causes and the prevalence of each of these causes. According to studies conducted, the prevalence of various causes of intestinal obstruction in the West and East of the world is different, and finding common causes in Shahrood, which is the goal of this research project, can lead the doctor to a better diagnosis. During the studies conducted, the most common cause of intestinal obstruction in some countries was obstruction following surgery, which causes adhesion and ultimately intestinal obstruction. Other common causes include malignancy and herniation. Of course, it should be noted that the most common cause of obstruction in some Asian countries is herniation, followed by malignancy and adhesion. Interestingly, TB ranks fourth on this list, and the reason for this is the prevalence of this disease in Asia, especially in Iran. These were followed by Intussuception, Volvulus, and then miscellaneous. (۱) Considering the different causes of intestinal obstruction mentioned in different geographical locations, investigating these causes in Shahroud shows its importance even more.

کلیدواژه ها:

Chronic Disease ، Gut ، Kidney ، Microbiota ، Health