Impact of Central Nervous System Involvement on Changes in WBC, Hemoglobin, Platelet Count, and LDH Levels in Pediatric Acute Leukemia

prognostic factor that may influence treatment strategies and outcomes. Identifying hematologic and biochemical markers associated with CNS infiltration could aid in early risk assessment.Materials and Methods: This retrospective cross-sectional study was conducted on ۸۷ children diagnosed with acute leukemia at Bou Ali Hospital in Ardabil between ۲۰۱۸ and ۲۰۲۲. Patients were categorized based on the presence or absence of CNS involvement, confirmed via cerebrospinal fluid analysis. Baseline laboratory parameters, including white blood cell (WBC) count, hemoglobin (Hb), platelet count (Plt), and lactate dehydrogenase (LDH), were compared between groups. Statistical analysis was performed using SPSS v۲۶, with a significance threshold of p < ۰.۰۵.Results: Among ۸۷ patients, ۱۴ had CNS involvement. Although mean WBC was higher and Hb and Plt levels were lower in the CNS-involved group, none of the differences were statistically significant (p > ۰.۰۵). LDH levels were nearly identical between groups.Conclusion: No significant association was found between routine laboratory parameters and CNS involvement in pediatric leukemia. However, observed trends suggest potential predictive value, warranting further investigation in larger, prospective studies.

کلیدواژه ها:

acute leukemia ، CNS involvement ، Pediatric Oncology ، Hematologic Markers