Association between vitamin D receptor BsmI (rs۱۵۴۴۴۱۰) gene polymorphism and serum vitamin D, serum calcium, and osteoporosis risk in women over ۴۰ years

Objectives: We investigated the relationships between the vitamin D receptor BsmI (rs۱۵۴۴۴۱۰) gene polymorphism, serum vitamin D and calcium levels, and the risk of osteoporosis in women aged ۴۰ years and older. Methods: This case-control investigation enrolled participants (۳۰ cases and ۳۰ controls) classified into normal and osteoporotic groups using a dual-energy X-ray absorptiometry (DEXA) scan. Vitamin D and calcium levels were obtained from peripheral blood samples. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the BsmI polymorphism. Differences between groups were analyzed using an analysis of variance (ANOVA) test. Results: ۶۰ individuals (۳۰ cases and ۳۰ age-matched controls) were enrolled. The lumbar and femoral T-scores, as well as calcium levels, were significantly lower in the cases compared to the controls (P < ۰.۰۰۵). Among postmenopausal women, the lumbar T-scores significantly differed between cases with VDR polymorphisms (P = ۰.۰۰۳) and controls (P = ۰.۰۰۱). Among premenopausal women, there was only a significant difference in VDR polymorphisms in the control group (P = ۰.۰۰۶). Calcium and vitamin D levels were significantly different between the VDR polymorphisms in cases and control groups, but only among postmenopausal women (P < ۰.۰۰۵ for all comparisons). No significant differences were observed between the VDR polymorphism in terms of femoral T-scores, neither in the cases nor the controls (P for all > ۰.۰۰۵). Conclusion: This study found no differences in VDR polymorphism between individuals with and without osteoporosis. Additionally, the lumbar T-scores, calcium, and vitamin D levels were significantly different between the VDR polymorphisms in the case and control groups among postmenopausal women.

کلیدواژه ها:

BsmI gene polymorphism ، vitamin D receptor ، osteoporosis ، post-menopause women