A retrospective study on clinical and Para clinical findings of Quetiapine toxicity cases admitted in Clinical Toxicology Center, Imam Reza Hospital for five years

Background: Quetiapine is a dibenzothiazepine-derived antipsychotic drug that has been evaluated for the management of patients with psychotic disorders. Quetiapine is associated with an increased risk of death in dementia-related psychosis in elderly patients. There is a risk of increased suicidal thoughts and behavior associated with drug treatment in patients with major depressive disorder.Objectives: Our study aims to investigate the patients with quetiapine poisoning within ۵ years.Methods: The files of patients who were poisoned by antipsychotic drugs during the study period were collected at the poisoning department of Imam Reza Hospital. Those who reported poisoning with Quetiapine were included in the study and analyzed. The checklist was prepared in advance, and information was entered into it. Based on the normality or not of the data distribution, parametric and non-parametric tests were used, and SPSS was used to analyze the data.Results: The number of ۳۱ cases was related to patients who registered poisoning with Quetiapine; ۱۵ were male (۴۸.۳۸%), and ۱۶ were female (۵۱.۶۱%). The average age of the patients was ۴۵.۲۵±۳۵.۵۱, and the average total dose consumed was ۷۴۵.۸۵±۲۴۲.۶۵. Also (۶۴.۵۱%) were discharged from the hospital with full or partial recovery, and no deaths were reported. Also, the average dose consumed had a significant relationship with QTC, WBC, level of consciousness, heart rate, and outcome (P<۰.۰۵), while no significant relationship was observed with other variables.Conclusion: According to the present study, Quetiapine has many side effects, the most being cardiovascular complications, which show the need for special clinical care related to the heart and blood vessels.

کلیدواژه ها:

Poisoning ، antipsychotic ، Quetiapine ، Para clinical complications