One-Pot multicomponent synthesis of substituted ۱,۶-naphthyridine derivatives employing ۱-naphthylamine and SiO۲/Fe۳O۴@ MWCNTs as organometallic catalyst

This research endeavor successfully synthesized ۱,۶-naphthyridine, an innovative category of fused heterocyclic compounds, with remarkable efficiency through the implementation of a multicomponent reaction. The reaction comprised benzaldehyde or its derivatives, two moles of malononitrile, and either ۱-naphthylamine in an aqueous medium at ambient temperature, utilizing SiO۲/Fe۳O۴@ MWCNTs as a recyclable catalyst. This investigation further explores the antioxidant characteristics of ۱,۶-naphthyridine in conjunction with the additional research conducted within this study. The synthesis protocol for ۱,۶-naphthyridine exhibited numerous advantageous attributes, encompassing expedited reaction times, elevated yields of the final product, and the ease of separating both the catalyst and product from the reaction mixture.

کلیدواژه ها:

Antioxidant activity ، Multicomponent reaction ، ۱ ، ۶-Naphthyridine ، Malononitrile