Recent progress in the direct sulfonylation of C(sp)-H/CO۲H bonds

The direct sulfonylation of terminal acetylenes and the decarboxylative sulfonylation of acetylenic acids are novel and straightforward approaches for preparing biologically and synthetically significant acetylenic sulfone derivatives. These methods offer several advantages over conventional protocols, including the utilization of inexpensive and readily accessible starting materials, improved atom and step economy, and reduced waste generation. This mini-review highlights recent advancements in these promising approaches to acetylenic sulfones, with an emphasis on the scopes, limitations and the mechanisms of the reactions.

کلیدواژه ها:

Decarboxylative functionalization ، C-H bond functionalization ، sulfonylation ، acetylenes ، acetylenic acids ، acetylenic sulfones