Toxins and Their Role in Disease Fate and Treatment: An Overview on Bacterial Toxins' Functions

سال انتشار: 1404
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 169

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شناسه ملی سند علمی:

JR_JABR-12-3_001

تاریخ نمایه سازی: 25 مهر 1404

چکیده مقاله:

Some bacteria can produce toxins that give them an environmental advantage by modifying the life cycle of nearby competing cells. Generally, bacteria that produce toxins are more capable of causing disease compared to those that do not. Most bacterial toxins directly target key enzymes or molecules within cellular pathways of affected cells. Closer examination reveals that bacterial toxins are active molecules capable of crossing biological barriers or altering essential factors in living cells. This review discusses new applications of bacterial toxins in biotechnology and medicine. Recently, scientists have used toxins like botulinum toxin for cancer therapy and treating various disorders in humans and animals, including muscle problems and Blepharospasm. In this overview, we highlight the pathogenicity of bacterial toxins and their potential use in therapy and prevention. Although we focus on the most important toxins, many others are either harmful or beneficial for different purposes.

نویسندگان

Ehsan Rezaei

Molecular Biology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Maryam Keshtvarz

Department of Microbiology and Parasitology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

Mostafa Khafaei

Human Genetics Research Center, Baqiyatallah Medical Science University, Tehran, Iran

Hamid Sedighian

Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Yousef Sefidi-Heris

Division of Molecular Cell Biology, Department of Biology, Shiraz University, Shiraz, Iran

Reza Kachuei

Molecular Biology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Abbas Ali Imani Fooladi

Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran