The Effect of Intravenous Ketamine Administration on Pain Severity in Patients Undergoing Nasal Surgery

Introduction: Understanding and optimizing postoperative pain management in nasal surgeries is critical, as inadequately controlled pain can impede recovery, increase morbidity, and compromise patient outcomes. Investigating the analgesic efficacy and safety profile of intravenous ketamine provides valuable insight into developing opioid-sparing, multimodal analgesic regimens. Material and methods: This double-blind, randomized controlled trial will assess the efficacy of intravenous ketamine versus placebo for postoperative pain in adult nasal surgery patients. Utilizing rigorous sampling, concealment, and blinding procedures, the study ensures methodological robustness. Comprehensive data collection on pain and adverse events will be analyzed with appropriate statistical methods. Results: The study demonstrated comparability between the ketamine and control groups at baseline; however, postoperative pain scores were consistently and significantly higher in the ketamine group at all measured time points up to ۲۴ hours post-surgery. These results indicate that intravenous ketamine did not provide the anticipated analgesic benefit for nasal surgery patients and was, in fact, associated with greater pain severity compared to placebo throughout the early and late postoperative periods.Conclusion: In conclusion, the study demonstrated that intravenous ketamine administration during nasal surgery did not confer the expected analgesic advantage; instead, it was associated with significantly higher postoperative pain scores compared to placebo at all evaluated time points. These findings challenge the presumed efficacy of ketamine for postoperative pain control in this context, underscoring the need for procedure-specific analgesic strategies and highlighting the importance of evidence-based approaches in perioperative pain management.

کلیدواژه ها:

Ketamine ، Postoperative pain ، Nasal Surgery ، analgesia