Changes in Micronutrient Levels During the First Trimester After One-Anastomosis Gastric Bypass with a ۱۵۰ cm Biliopancreatic Limb

Introduction: One-anastomosis gastric bypass (OAGB) with a ۱۵۰ cm biliopancreatic limb is increasingly used as a bariatric surgery option, offering effective weight loss and metabolic benefits. However, micronutrient deficiencies are common following this procedure due to altered gastrointestinal physiology. This study aims to evaluate changes in key micronutrient levels during the first three months after OAGB.Materials and Methods: This prospective observational study included ۲۵ patients who underwent OAGB with a ۱۵۰ cm biliopancreatic limb. Blood samples were collected at three time points: preoperatively, ۱ month postoperatively, and ۳ months postoperatively. Serum levels of iron, ferritin, vitamin B۱۲, folate, calcium, vitamin D, and fat-soluble vitamins (A, D, E, K) were measured. Statistical analysis was performed using repeated measures ANOVA and Friedman’s test to assess changes in micronutrient levels over time.Results: The study found significant decreases in ferritin, vitamin B۱۲, calcium, and fat-soluble vitamins (A, E, and K) from baseline to ۳ months post-surgery (p < ۰.۰۵ for all). Ferritin and vitamin B۱۲ levels declined sharply, indicating potential iron and vitamin B۱۲ deficiencies, while vitamin D and calcium levels also decreased, raising concerns about bone health. Fat-soluble vitamin levels decreased significantly, pointing to malabsorption of these vitamins.Conclusion: Significant micronutrient deficiencies, particularly in iron, vitamin B۱۲, calcium, and fat-soluble vitamins, were observed within the first three months after OAGB. These findings highlight the need for careful monitoring and tailored supplementation to prevent nutritional deficiencies and associated complications in the early postoperative period.

کلیدواژه ها:

One-anastomosis gastric bypass ، Micronutrient deficiencies ، Postoperative monitoring ، Nutritional supplementation