Ni-Modified BN Nano cones as ۵ -fluorouracil Nanocarrier

۵-fluorouracil (۵ -Fu) is a chemotherapy agent, widely used to treat different cancers including breast, colorectal, pancreatic, liver, gastric, and squamous cell carcinomas. This drug has a heterocyclic structure like the pyrimidine ring in DNA and RNA. Therefore, it can be incorporated into RNA and DNA by interfering with nucleoside metabolism, leading to cytotoxicity and cell death. However, ۵ -Fu has serious side effects, such as myotoxicity, hand -foot syndrome, and cardiotoxicity. Furthermore, it causes chest pain, low blood count, and cognitive impairment, which limits its efficiency. Also, the low bioavailability of ۵ -fu is a significant limitation of its use in its clinical applications. Lately, extensive studies have focused on improving the absorption and minimizing the adverse reactions of chemotherapy medications. The extensive development of nanotechnology in recent decades has led to the emergence of prominent ideas and strategies for the treatment and diagnosis of incurable diseases. A fundamental challenge in implementing intelligent drug delivery is finding a suitable carrier. An ideal drug carrier does not harm the structure and therapeutic effect of the drug. Also, its structure should be such that its electrical characteristics and optical properties alter in drug -bound and free states. In this way, it becomes possible to determine the location of the drug in the human body using identification techniques. In this study, BN nanocone and its Ni -modified derivatives have been examined for their capability of ۵ -Fu delivery.

کلیدواژه ها:

doping ، BN Nanocones ، ۵ -fluorouracil ، Nanocarrier