Design of Wearable Electrochromic Sensor based WO ۳/Cu-Fe MOF for On -Site Visualized Monitoring of Ketone Bodies

Electrochromic sensors are electrochemical devices that use color changes for simplified construction and instrumentation. They can operate without enzymes or multiple oxidant reagents. These sensors can detect various analytes, like ketone bodies, based on the sensitivity of the electrochromic material to specific stimuli, such as protons. Ketone bodies including β-hydroxybutyrate (BHB), acetoacetate and acetone are produced in the liver because of fatty acid oxidation, as an alternative energy source in response to glucose deficiency. BHB, as one of the most abundant ketones, is an important biomarker used to clinically diagnose and monitoring the status or severity of conditions related to diabetes and complications associated with ketogenic diets. Compared to conventional approaches that rely on samples of urine or blood evaluated using laboratory techniques, processes for monitoring of ketones in sweat using on-body sensors offer significant advantages. In the study, a soft, skin-interfaced microfluidic device fabricated that can quantify the concentrations of BHB in sweat based on simple and low-cost electrochemical-colorimetric dual-mode biosensor. With the designed electrochromic sensor, it was aimed to detect the color change of the electrochromic material with change in the BHB concentration by the naked eye and to develop a selective ketone bodies sensor by molecular imprinted polymer technology. Electrochromic sensor based WO ۳/Cu-Fe metal organic framework (MOF) exhibited linear response with BHB concentrations in real sweat, the range of ۲۰-۱۵۰ μM with a detection limit of ۱۰ μM.

کلیدواژه ها:

Electrochromic sensor ، Electrochemical-colorimetric biosensor ، Metal organic framework ، β-hydroxybutyrate