Omega ۳-Induced Autophagy: A Two-Sided Sword in Cell Death from Historical Perspective in Clinical Application and Biological Mechanisms

Omega-۳ fatty acids, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA), are polyunsaturated fatty acids (PUFAs) with numerous health benefits. They play a critical role in various cellular functions, such as maintaining cell membrane integrity, cellular signaling pathways, and cell-to-cell communication. Omega-۳s are known for their anti-inflammatory, anti-cancer, anti-depressant, and lipid-lowering properties. Autophagy, a cellular process responsible for recycling and degrading cellularcomponents, is closely linked to these fatty acids. The impact of omega-۳ fatty acids on autophagy signaling pathways hold promise for innovative therapeutic strategies in disease management and overall well-being. This review explores the influence of omega-۳ fatty acids on autophagy and provides insights into the potential mechanisms involved.

کلیدواژه ها:

Cellular autophagy ، Omega-۳ ، Cell death ، Docosahexaenoic acid ، Eicosapentaenoic acid