The Effect of Fermented Green Fern Extract (S. palustris) on Tumor Necrosis Factor-Alpha and Superoxide Dismutase Levels in Malnourished Rats

Background: Malnutrition in children is still a global issue that can significantly impact the immune function and increase the susceptibility to oxidative stress. This study investigated the potential of fermented S. palustris on oxidative stress markers, specifically Superoxide Dismutase (SOD) and Tumor Necrosis Factor-alpha (TNF-α), in malnourished rats.Methods: The rats were divided into five groups of healthy controls, malnourished without intervention, and malnourished groups receiving varying doses of S. palustris extract (۱۰۰, ۳۰۰, and ۵۰۰ mg/kg) for ۲۸ days.Results: A significant increase in SOD level in all intervention groups was noticed with the highest increase in ۵۰۰ mg/kg group (D۳) that approached the level of the healthy control group. TNF-α level significantly decreased in the intervention groups, with the ۳۰۰ mg/kg (D۲) group showing the greatest reduction.Conclusion: Fermented S. palustris extract was shown to enhance antioxidant properties and reduce inflammation in malnourished animals that can offer a promising strategy for nutritional interventions in malnutrition-related disorders.

کلیدواژه ها:

Malnutrition ، Stenochlaena palustris ، Fermentation ، superoxide dismutase ، Tumor necrosis factor-alpha