The Effect of Resistance Training On Serum Adropin, Fetuin-A, and Insulin Resistance in Overweight Women

Introduction: Overweight is associated with disturbances in serum levels of adipokines and cytokines that affect metabolism and insulin action.In this study, we aimed to assess the effect of resistance training on serum adropin, fetuin-A, and insulin resistance in sedentary overweight women. Methods: In this quasi-experimental study, ۲۴ overweight women aged ۲۵-۳۵ (BMI between ۲۶ and ۳۰) were randomly divided into exercise and control groups. The exercise group participated in an ۸-week resistance training program (three times per week), while the control group continued their sedentary lifestyle. Fasting blood samples were obtained from the brachial vein before the training program and ۴۸ hours after the final exercise session to measure serum adropin, fetuin-A, glucose, insulin, and insulin resistance. Results were then compared between the two groups. Results: Resistance training resulted in a significant decrease in serum fetuin-A (p=۰.۰۱۴), glucose (p=۰.۰۰۳), and insulin resistance (p=۰.۰۱۱), and a significant increase in serum adropin (p=۰.۰۲۱). No significant changes were observed in the control group for fetuin-A (p=۰.۴۱۳), glucose (p=۰.۳۵۱), adropin (p=۰.۵۳۹), or insulin resistance (p=۰.۱۳۷). Conclusion: Based on our findings, improvements in insulin resistance can be attributed to changes in serum adropin and fetuin-A in response to resistance training. Identifying the mechanisms responsible for these changes requires further studies in this field.

کلیدواژه ها:

Overweight ، Resistance training ، insulin resistance ، Fetuin ، Adropin