Association of the SLC۶A۳ Gene rs۲۶۵۲۵۱۱ Polymorphism with Methamphetamine Abuse Disorder in the Iranian Population

Background: Besides its physical and psychological effects on individuals, addiction is a major personal and societal issue that threatens cultural, political, and community well-being. Genetic factors play essential roles in susceptibility to methamphetamine dependence. The purpose of this study was to investigate the correlation between methamphetamine use disorder in Iranian males and the rs۲۶۵۲۵۱۱ polymorphism in the promoter of SLC۶A۳.Methods: We recruited ۱۰۰ men with methamphetamine use disorder as cases and ۱۰۰ age- and ethnically-matched normal men from East Azerbaijan, Tabriz, Iran as healthy controls. From peripheral blood leukocytes, genomic DNA was extracted. PCR-RFLP was utilized for genotyping.Findings: The genotype distribution of rs۲۶۵۲۵۱۱ polymorphism in the case group was ۵۶% CC, ۳۳% CT, and ۱۱% ۴۴, whereas in the control group it was ۲۵% CC, ۴۲% CT, and ۳۳% TT. According to statistical analysis, there was a substantial variation in genotype and allele frequencies of the rs۲۶۵۲۵۱۱ polymorphism between the case group and the healthy control group (P > ۰.۰۵).Conclusion: Our research revealed that the rs۲۶۵۲۵۱۱ polymorphism in the SLC۶A۳ gene was associated with methamphetamine misuse disorder in the Iranian population. To clarify the exact role of this polymorphism in the pathology of methamphetamine use disorder, further research is required across different racial and geographic groups.

کلیدواژه ها:

Methamphetamine use disorder ، SLC۶A۳ gene ، Polymorphism