The Potential Role of MicroRNAs in Cardiac Myxoma: A comprehensive Review on the Current Evidence

Cardiac myxoma (CM) is the most common primary cardiac tumor, often benign but potentially life-threatening due to embolic events and intra-cardiac obstruction. Recent advances suggest a significant role for microRNAs (miRNAs) in CM pathogenesis, diagnosis, and treatment. This review aims to synthesize current evidence regarding the diagnostic implications of miRNAs in cardiac myxoma. Several miRNAs, including miR-۲۱۷, miR-۲۱۸, miR-۳۳۵, miR-۳۲۰a, miR-۱۲۲, and miR-۶۳۴, have been implicated in regulating proliferation, apoptosis, inflammation, and differentiation in CM. Notably, miR-۲۱۷ and miR-۲۱۸ act as tumor suppressors, while dysregulated pathways involving Myocyte Enhancer Factor ۲D (MEF۲D) and Interleukin-۶ (IL-۶) further elucidate the molecular basis of tumor progression. Circulating miRNA profiles also offer potential as non-invasive diagnostic biomarkers. miRNAs offer promising avenues for both early detection and targeted therapy in cardiac myxoma. Further research into miRNA-based diagnostics and therapeutics may enhance personalized treatment and reduce recurrence risk in affected patients.

کلیدواژه ها:

Cardiac Surgery ، Cardiac tumors ، microRNAs ، myxoma