Effects of pressure sensitive adhesives and chemical permeation enhancers on rat skin permeation of nitroglycerin

سال انتشار: 1384
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 1,785

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

NICEC10_468

تاریخ نمایه سازی: 6 بهمن 1385

چکیده مقاله:

Different drug in adhesive patches (DIAPs) of nitroglycerin were formulated using various pressure sensitive adhesives (PSAs) and various chemical permeation enhancers (CPEs). The effects of the PSAs and CPEs on skin permeation of nitroglycerin from DIAPs were evaluated using modified jacketed Franz diffusion cells fitted with excised rat abdominal skins. It was demonstrated that permeation rate or steady state flux (Jss) of the drug through the excised rat skin was dependent on the viscosity and type of acrylic PSA as well as the type of CPE. Among different acrylic PSAs, Duro-Tak® 2516 and Duro-Tak® 2051 showed the highest Jss 200.8 µg cm-2 h-1 and lowest Jss 112.4 µg cm-2 h-1, respectively. Among the various CPEs used, propylene glycol and cetyl alcohol showed the highest and lowest enhancement on the skin permeation of nitroglycerin, respectively. Oleic acid and cetyl alcohol moderately increased the skin permeation of nitroglycerin. It was also shown that increasing the concentration of CPE led to reduction in adhesion property of PSA as measured by 180° peeling strength test.

نویسندگان

Houman Savoji

Chemical & Petroleum Engineering Department, Sharif University of Technology

Ramazani

Chemical & Petroleum Engineering Department, Sharif University of Technology

Mehdizadeh

۲Hakim Pharmaceutical Co

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • 1. R. H. Guy, Current status and future prospects of ...
  • M. A. Ashburn, The p harmacokineti cs of transdermal nitroglycerin ...
  • B. W. Barry, Novel mechanism and devices to enable successful ...
  • A. M. Hillery, A. W. Lloyd and J. Swarbrick, Drug ...
  • R. Panchagnula, Transdermal delivery of drugs, Ind. J. Pharm. 29 ...
  • V. Carelli, G. Di Colo, E. Nannipieri and M. F. ...
  • R. Baker, Controlled Release of Biologically Active Agents, John Wiley, ...
  • E. S. Park, S. J. Chang, Y. S. Rhee and ...
  • J. H. Kim, Y. J. Cho and H. K. Choi, ...
  • D. A. Dimas, P. P. Dallas, D. M. Rekkas and ...
  • M. Guyot and F. Fawaz, Design and in vitro evaluation ...
  • T. M. Goulding, Handbook of Adhesive Technology, Marcel Dekker, New ...
  • D. G. Maillard- Salin, P. Becourt and G. Couarraze, A ...
  • P. Minghetti, F. Cilurzo and L. Montanari, Evaluation of adhesive ...
  • A. Mehdizadeh, T. Toliyat, M. R. Rouini and S. Abashzadeh, ...
  • A. Mehdizadeh, T. Toliyat, M. R. Rouini, S. Abashzadeh and ...
  • Y. W. Chien, Novel drug delivery systems, _ Marcel Dekker, ...
  • ax Iranian Chemical Engineering Congress (IChEC10), Sistan & Balochestan University ...
  • G. S. Banker and C. T. Rhodes, Modern Pharmaceutics, _ ...
  • _ Puglia, F. Bonina, G. Trapani, M. Franco and M. ...
  • P. Chedgzoy, G. Winckle and C. M. Heard, Triclosan: release ...
  • ax Iranian Chemical Engineering Congress (IChEC10), Sistan & Balochestan University ...
  • نمایش کامل مراجع